IMP-33, a New IMP Variant Detected in Pseudomonas aeruginosa from Sicily

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IMP-33, a New IMP variant detected in Pseudomonas aeruginosa from Sicily.

Avariety of metallo-lactamase (M L) enzymes have been reported from Gram-negative organisms collected in Italy, including VIM-1, the second acquired M L to be reported; IMP-13; VIM-2; IMP-19; and FIM-1 (1–6). A survey conducted from September to December of 2004 in 12 Italian cities demonstrated a low overall prevalence of carbapenemase-producing organisms, but these strains were widespread acr...

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Nosocomial outbreak of carbapenem-resistant Pseudomonas aeruginosa with a new bla(IMP) allele, bla(IMP-7).

Pseudomonas aeruginosa isolates from an outbreak in Canada were highly resistant to carbapenems and ceftazidime but not piperacillin. They produced a novel integron-associated metallo-beta-lactamase, designated IMP-7, with 91% identity to IMP-1. bla(IMP-7) was not detected with standard bla(IMP)-specific primers, owing to mismatches in the forward primer.

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Identification of bla(IMP-22) in Pseudomonas spp. in urban wastewater and nosocomial environments: biochemical characterization of a new IMP metallo-enzyme variant and its genetic location.

OBJECTIVES The aim of the study was the biochemical characterization of a new variant of the metallo-beta-lactamase, IMP-22. Moreover, the genetic environment of the bla(IMP-22) gene was investigated in Pseudomonas fluorescens and Pseudomonas aeruginosa collected from urban wastewater and a teaching hospital in L'Aquila, Italy. METHODS Molecular characterization of genetic elements was carrie...

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Draft Genome Sequence of an IMP-7-Producing Pseudomonas aeruginosa Bloodstream Infection Isolate from Australia

IMP-7 is one of the two IMP-type carbapenemases that in Pseudomonas aeruginosa are not limited to a geographic area, but it has not been previously reported in the Australian setting. We report here the draft genome sequence of an Australian P. aeruginosa bloodstream infection isolate that contains IMP-7.

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The early eighties saw the introduction of a new group of antibiotics known as the carbapenems, which exhibited broader spectrum of activity as compared to cephalosporins. These group of antibiotics were active against Gram negative bacilli including non-fermenters like Pseudomonas producing extended spectrum betalactamases (ESBLs) and AmpC betalactamases (Deshpande et al., 2004; Gladstone et a...

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ژورنال

عنوان ژورنال: Antimicrobial Agents and Chemotherapy

سال: 2013

ISSN: 0066-4804,1098-6596

DOI: 10.1128/aac.02532-12